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Jul 16, 2024null min read

Efficacy and Safety of Teosyal RHA® 4 for Treating Nasolabial Folds: Cannula vs. Needle

The emergence of nasolabial folds (NLF) is one of the earliest signs of aging, prompting many to seek aesthetic treatments. Teosyal RHA® 4, part of Teoxane's Resilient Hyaluronic Acid (RHA) fillers dynamic range, is a popular procedure. This study aimed to compare the effectiveness and safety of injecting RHA 4 using a cannula versus a needle for treating moderate to severe NLFs.

In this multicenter clinical trial, 50 adult participants with moderate to severe NLFs received RHA 4 injections on both sides of their faces: one side with a cannula and the other with a needle. The injections were randomized to ensure unbiased results.

Both injection methods significantly reduced NLF severity by week 12. The mean improvement was nearly identical: -1.61 for the cannula side and -1.65 for the needle side, demonstrating that the cannula is non-inferior to the needle.

Over 90% of participants were satisfied with their treatment, regardless of the injection method. Only a small number of participants (10%) were not fully satisfied, evenly split between the two methods.

Common reactions included bruising, lumps, redness, itching, and pain, but these were generally mild and resolved quickly. The cannula method showed a slightly lower incidence of these reactions compared to the needle.

Both methods had a similar rate of treatment-related adverse events (TRAEs), mostly mild and related to the injection site. No serious or unexpected adverse events were reported.

This study confirms that Teosyal RHA® 4 is equally effective and safe whether injected with a cannula or a needle. Both methods provide excellent results and are well tolerated when performed by trained practitioners. Patients can be confident in achieving natural-looking corrections of their nasolabial folds with Teosyal RHA® 4, regardless of the injection technique used.

Read the full version :  Beer K, Biesman B, Cox SE, Smith S, Picault L, Trevidic P. Efficacy and Safety of Resilient Hyaluronic Acid Fillers Injected with a Cannula: A Randomized, Evaluator-Blinded, Split-Face Controlled Study. Clin Cosmet Investig Dermatol. 2023 Apr 6;16:959-972.